IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

THE IMPACT OF HERBAL INFUSION KAHWAH ON OXIDATIVE STRESS AND BREAST CANCER IN MOUSE MESENCHYMAL STEM CELL LINE C3H10T1/2 AND MCF-7

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Gulafshan, Parijat Singowal, Mridul Sharma, Parwati Pant, Dr. Seemha Rai

Abstract

Obese people are more likely to develop triple-negative breast cancer (TNBC), which is linked to a condition of chronic low-grade inflammation. Epidemiological studies, on the other hand, showed that Increased consumption of polyphenol-rich fruits and vegetables appears to play a crucial role in lowering the prevalence of certain cancers. In addition to natural products, Kahwah (a mixture of green tea and spices) have many desirable properties so that they can be used for medicinal purposes. The Kahwa is an exotic blend of Kashmiri green tea leaves, whole spices, luscious saffron, and nuts steeped in a special kettle known as a samovar. Saffron is high in vitamin B12 and antioxidants, which help with immunity, stress relief, and digestion. Saffron, cardamom, cinnamon, clove, and green tea leaves Spices'' effects on various types of stem cells have been studied in several studies Dietary-derived polyphenols have been shown to modulate stem cell self-renewal, which has implications for disease management and prevention The present study was designed to investigate the primary effect of kahwah extract on murine mesenchymal stem cells and MCF-7 cell line by observing its effects on its viability, cytotoxicity, rate of cell proliferation, and migration along with its antioxidant potential observations of the present study demonstrated that Kahwah encumber the formation of mature adipocytes in the mesenchymal stem cells following exposure to adipogenic differentiation medium and inhibits the proliferation of MCF-7 cells upon administration of kahwah doses. Based on the observations, it is appropriate to claim that kahwah, having flavonoids majorly EGCG, possesses the ability to limit the proliferation of cancer cells and mesenchymal stem cells differentiation to adipogenic lineage. This could offer a logical strategy for creating kahwah as a flexible model for the treatment of obesity-related illnesses, such as carcinogenesis.

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