Background: Xylitol is a five-carbon sugar alcohol, providing some context. Plums, strawberries, and raspberries all contain xylitol naturally. In some countries, xylitol is commercially accessible in chewing gum, lozenges, syrups, nasal sprays, toothpastes, and mouthwashes. In the past decade, it has risen to popularity as a naturally occurring antibacterial agent. Aim’s & Objectives: the efficacy of xylitol usage in ENT practise, a review of the current literature was done. Methods & Materials: A literature search was conducted using the following terms: xylitol, middle ear infection, nasal, sinusitis, dental caries, and preventative therapy. The identified articles are included in this review. Results: Xylitol has no inherent antibacterial capabilities; rather, it appears to boost the body's innate defences. Xylitol inhibits the growth of microorganisms such as Streptococcus pneumoniae and Streptococcus mutans by decreasing their ability to adhere. Xylitol has been used to prevent middle ear infection, rhinosinusitis, and dental caries. The global expansion of drug-resistant pneumococci strains demonstrates the need for innovative strategies to avoid ENT-related infectious illnesses. Conclusion: Xylitol may be a viable drug for this purpose in ENT therapy, although additional experimental and clinical research is necessary