IJFANS International Journal of Food and Nutritional Sciences
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Efficacy of Withania somnifera against oxidative stress in male Drosophila melanogaster.
Volume 13 | Issue 4
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Intervention Study On Cognitive Development Among School Children Of Siddi Tribe
Volume 13 | Issue 4
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ASSESSMENT OF INTRA AND INTER- EXAMINER RELIABILITY FOR PROPOSED SCALE OF MASTICATION IN CHILDREN– A PRELIMINARY STUDY
Volume 13 | Issue 4
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AI-DRIVEN APPROACH FOR MULTI CROP DISEASE CLASSIFICATION WITH PESTICIDE RECOMMENDATION SYSTEM
Volume 13 | Issue 4
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AI-based Detecting Deception In Online Interactions: An Analysis of Dishonest Internet Users for Advances In Online Security
Volume 13 | Issue 4
Synthesis of Newer Substituted of Thiazoles Analogues and Study for Anticancer Activity
Main Article Content
Abstract
A novel series of thiazole were designed and prepared via the reaction of the 4-(naphthalene-5-yl) semicarbazide of appropriate different aldehydes groups (ArCHO) was added and contained in a round bottom flask. Thiazole compounds are selected for 3 Compound (3a, 3c & 3f) were evaluated for their anticancer activity in one dose assay and showed moderate activity on various cell lines. Compound 5-(4-nitroyphenyl)-N-(naphthalen-5-yl) thiazol-2-amine (3c) showed maximum activity with growth percent (GP) of 58.13 on SR (Leukemia), 75.57 on NCI-H522 (Non-Small Cell Lung Cancer A549/ATCC) and mean growth percent (GP) of 94.11. And Compound 5-(3,4,5-trimethoxyphenyl)-N-(naphthalen-5-yl) thiazol-2-amine (3f) showed maximum activity with growth percent (GP) of 68.75 on T-47D (Breast Cancer), 64.16 on NCI-H522 (Non-Small Cell Lung Cancer A549/ATCC), 85.74 on SNB-75 (CNS Cancer) and mean growth percent (GP) of 91.22.
