This study developed sustained-release matrix tablets of ketorolac tromethamine using natural (Hibiscus rosa-sinensis leaves mucilage) and synthetic (Hydroxy Propyl Methyl Cellulose) polymers at varying concentrations (20%, 40%, and 60%). Seven formulations were prepared, each maintaining 40 mg of ketorolac tromethamine while adjusting excipient levels. The tablets were evaluated for physical characteristics, including appearance, weight variation, thickness, hardness, and friability. Drug release was assessed through dissolution testing, with data analyzed using kinetic models. The combination of Hibiscus mucilage and HPMC achieved a 46% drug release over 10 hours, demonstrating the potential of using both natural and synthetic polymers to control drug release effectively. This study contributes to the development of sustained-release matrix tablets for ketorolac tromethamine.