Drift towards organic food habits, natural lifestyle concerns and naturopathy medicine mediatable topic in these days. It also helps in lowering the multi-drug resistance. The natural antimicrobials can be obtained from different sources like fruits, vegetables, bacteria, algae and some meat sources. Citrus fruit, berries and pomegranate or rich in natural antimicrobials. Cabbage, cauliflower, broccoli, Brussels sprout, horseradish, mustard seeds or against the E. coli, Salmonella, Shigella etc. India has been using spices has an antimicrobial from its ancient history. Spices like turmeric, pepper, Ginger and cinnamon are being widely used across the nation. The knowledge and the use of natural antimicrobials have been drastically increased during pandemics and post Covid-19 pandemic period.