Comparison of platelet rich plasma's (PRP) effectiveness in tympanoplasty. Tympanoplasty research comparing the two methods. 50 patients with moderate to large central perforations underwent type I Tympanoplasty under LA via the post-auricular route. Those in the control group had surgery without PRP. Tympanoplasty was added to the study group with PRP by injecting PRP-soaked gel foam into the middle ear, over the graft, and into the bone canal, as well as wetting the temporal fascia with PRP graft. Audiometry was performed both before and after the operation. comparing the outcome, the majority of the patients were in the 25– 30 age range. In the control group, the graft uptake success rate was 84%; in the PRP group, it was 97%. [1] Improvements in hearing were 40% in the control group and 82.0% in the PRP group. According to this study, adding PRP to type I tympanoplasty procedures increases the likelihood that the graft would accept the tissue and mend early, leading to an improvement in hearing.