Distraction osteogenesis (DO) is a tissue engineering technique used to regenerate new bone. It is a bone-lengthening procedure that stretches the skull, midface, and mandibular bones. It has effectively treated a number of facial deformities like craniosynostosis, midface hypoplasia, and mandibular hypoplasia. The application of DO in the field of oral and maxillofacial surgery represents a promising alternative as it can be integrated with conventional surgical techniques for bone lengthening or enlargement. This technique offers excellent bone lengthening, has the advantage of eliminating the need for autograft and donor site morbidity, can be used in younger patients, and allows simultaneous expansion of the surrounding soft tissue. However, this technique requires a thorough understanding of the clinical and technical components to avoid potential complications, including recurrence, infection, damage to adjacent structures, device failure, and other complications, is needed.