The heavy metal cadmium is widely dispersed in environment and has no known advantages to humans. Cadmium exposure has been associated with adverse toxic effects in various target organs like liver, kidneys including the ovaries. It is now recognized that exposure of Cadmium to animals and humans must be minimized. Despite the effect of cadmium exposures on female reproduction in animals, only a few studies have been conducted on this topic. The purpose of the present study was to evaluate the effect of vitamins C and E supplementation on Cadmium-treated female wistar albino rats. Therefore, the rats were orally administered different concentrations of cadmium chloride (3/5/7mg/ltr) with vitamins C and E (100mg/kg b.w.) to assess the effect of the vitamins in combating Cadmium-induced cytotoxicity and other manifestations. The tissue and blood samples were taken from the rats for histological evaluation and biochemical analyses after 14 days. Haematological analysis, serum biochemical analysis, histopathology of ovarian, kidney, liver tissues and serum hormonal assays were investigated. Histology of ovary, kidney and liver tissues of the group of female rats treated with 3/5/7mg/ltr showed evident ovary damage. All the experimental groups that were recovered with Vitamin C and E along with cadmium showed significant protective effect on all the biochemical and histological parameters studied. The results obtained in the present study clearly demonstrate that co- administration of vitamin C and E had nearly the same protective effects against Cadmium toxicity at the tissue level. They both have beneficial effects in the amelioration of Cadmium toxicity.