Many health care personnel have a higher risk of accidental needle stick injuries (NSI) due to the nature of their workplace. These employees run the danger of contracting blood-borne infections like HIV, hepatitis B and C, and other illnesses as a result of their employment. It is also crucial that healthcare personnel have proper training on how to handle sharp objects. Effective reporting mechanisms should be installed in all healthcare facilities to enable early case reporting and prompt action to address the situation by administering appropriate PEP and treatment, in addition to giving information and sufficient training to healthcare providers. Traditional schedule: 0,1,6 months, Recent guidelines: 0,1,4 months, Method: Intramuscular (deltoid), Side effects: pain at injection site, fever Anti-HBs > 10mIU/ml is protective level. As early as possible, ideally within 72 hrs Exposures that doesn’t require PEP when the exposed individual is already HIV positive when the source is established to be HIV negative; exposure to bodily fluids that does not pose a significant risk: tears, non-blood-stained saliva, urine and sweat. It has been concluded that infection risk after needle stick for HIV is 0.3% and the preventive step is to act as soon as possible within hours. The infection risk after needle stick for HBV is approximately 0 % with pep and 6% to 30% without pep and the preventive step is to act within 24 hours and no later than seven days. The infection risk after needle stick for HCV is 1.8% and there are no preventive steps are recommended.