The present paper is based on Ayurvedic disease “Prameha.” Here we can compare it with modern disease “Diabetes”. In the ancient Ayurvedic texts Prameha is considered as a syndrome that includes clinical conditions involved in obesity, prediabetes, diabetes mellitus, and metabolic syndrome. The factors that contribute to the production of prameha would impair all three doshas, namely Vata, Pitta, and Kapha. According to Charaka Prameha is a Kulaj Vikar (Hereditary) and Jataj Prameha (Juvenile diabetes) is Incurable. Dosh Dushya Sangraha of Prameha is as- Dosha- Kapha, Pitta, Vata. Involved Dushya are Rasa, Rakta, Mamsa, Meda, Majja, Shukra, Oja, Ambu, Vasa, and Lasika as mentioned in Ashtomahagada. Prameha in ayurveda is syndrome which includes the condition which refer to alter the urine matabolism in terms of frequency of micturition, quality, color and quantity of urine. It also associated with obesity, prediabetes, diabetes mellitus, and metabolic disorders. There are many references for Ayurvedic management of Prameha that we have to apply in modern time. Finally main intention for presenting this paper is to share basic details of Prameha for proper Treatment.