Domperidone is an antagonist works on dopamine receptor and act as antinauseant and antiemetic. Chemically it is 5-chloro-1-[1-(2,3-dihydro-2-oxo-1H-benzimidazole-1- yl)propyl)-4-piperidyl]-2,3-dihydro-1H-benzimidazol-2-one1.Domperidone belongs to BCS Class-II drugs having poor water solubility and higher permeability. Commonly, the average dose of domperidone is 10 mg/day. It is an anti-sickness drug used to provide relief in vomiting and nausea as well as to avoid the feeling of sickness. It can be used as a drug of choice for stomach pain treatment if palliative care is not available. The most frequent side effect of this drug is dry mouth that’s why it is recommended to be used for short period therapy but this side effect is usually varies from patient to patient like 1 in 100 people. This drug is not usually prescribed for the patients having GIT hemorrhage, perforation diseases and mechanical obstruction. In this review paper, the physicochemical, pharmacological and pharmaceutical characteristics of domperidone drug have been discussed in elaborative way along with various attempts performed by the formulation scientists to improve its pharmaceutical properties like solubility and dissolution behavior