IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Pediatric Pharmacology, Clinical Applications, and the Safety Profile of Dexmedetomidine

Main Article Content

Dr. Vaishali Lote1*, Dr. Shaktibala Dutta2 , Dr. Jyotsna Sharma3

Abstract

Dexmedetomidine is an a2-adrenoceptor agonist having sedative, anxiolytic, and analgesic characteristics, and it is one of the most important drugs in the industry. Because it is effective and does not have any negative effects on the respiratory system, it is sometimes used in paediatric patients even though it is not approved for that usage. Adults run the risk of developing severe cardiovascular problems if they use dexmedetomidine. In spite of its widespread use, dexmedetomidine has not been subjected to a significant amount of research to determine whether or not it is safe for children. This article provides a comprehensive assessment of the most recent research (up to the year 2010), with a particular emphasis on the uses and safety of dexmedetomidine when it is given to young patients. What benefits are in store for the reader: In the paediatric critical care unit, as well as during diagnostic and therapeutic operations, dexmedetomidine is a helpful medicine that serves as both a sedative and an anxiolytic. Both low blood pressure and a slow heart rate are undesirable side effects of the drug dexmedetomidine. In addition, hypertension can appear during the "loading dosage" or when the infusion rate is too high. Dexmedetomidine may have detrimental effects on the cardiovascular system, despite the fact that it has a good respiratory profile. It is recommended that careful titration and close monitoring of the circulatory dynamics be performed. Additional research is required to better determine harmful effects during longterm infusions as well as in particular populations such pre-term newborns. These populations will require special attention.

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