Neoplasm is a significant public health concern globally, including in Mumbai, India. This research aims to analyze neoplasm trends in Mumbai over the past two decades and predict future neoplasm models using retrospective data analysis. The study examines the prevalence and incidence rates of various types of neoplasms, identifies risk factors, and proposes potential strategies for neoplasm prevention and control. The findings of this research will contribute to the understanding of neoplasm epidemiology in Mumbai and assist in developing targeted interventions to reduce the burden of neoplasm in the city.