Various tree nuts include a wide range of chemical compounds that promote glucose homeostasis, thus averting the occurrence of Diabetes Mellitus (DM) and also play substantial role in preventing the onset of cardiovascular diseases (CVDs). Growing body of evidence and statistics from epidemiologic and clinical studies suggests that eating nuts may be a beneficial dietary strategy for preventing and treating Type 2 Diabetes Mellitus (T2DM) and related CVDs. The goal of this review is to understand the health consequences of tree nut consumption, the functional mechanism underlying nut consumption in supporting good health, and to dispel myths about tree nut consumption. The unique nutritional composition and bioactive compounds found in nuts may be the source of their health advantages. There is some risk associated with the infrequent occurrence of nut allergy in youngsters. Nut consumption has been demonstrated in trials to lower cholesterol, and there is also emerging evidence of favourable benefits on inflammation, oxidative stress, and vascular reactivity. It has been demonstrated that frequent consumption of tree nuts does not lead to obesity and may rather aid in weight loss. Further research on patients suffering from CVDs, diabetes, hyperlipidemia, and obesity is essential. This would provide fresh insights into the health advantages of nuts as well as validate the influence of nuts on lipoprotein blood serum levels depending on the time and manner of consumption.