The lumpy skin disease virus, or LSDV, belongs to the Capri poxvirus genus and family of Pox viridae and is the culprit behind lumpy skin disease (LSD). Cattle and water buffaloes are affected by this trans-boundary disease, which has a high morbidity and low fatality rate. With a 7.1% morbidity rate among cattle, lumpy skin disease has just been discovered for the first time in India. Typically, the disease's clinical symptoms include fever, anorexia, and distinctive nodules on the skin and mucous membranes of the mouth, nostrils, udder, genital, and rectum. The condition can also cause abortion, infertility, and occasionally even death. The contagious viral disease known as monkey pox, on the other hand, causes skin lesions that are identical to those of the former. Animals then people were exposed to it. This virus is a fresh worry, as was the discovery of newly emerging monkey pox cases outside of the African Continent in May 2022. Due to global travel and the trade of specific species, it demonstrated its spread to other parts of the world. Therefore, it is crucial to assess and talk about how to treat human infections with monkey pox in order to stop the disease from spreading. This study seeks to provide an overview of recent advances in epidemiology with an emphasis on zoonotic and trans-boundary dissemination, aetiology and transmission, clinical manifestations, diagnostics, and treatment of both illnesses with widespread skin lesions