The goal of the current experiment was to develop and assess a controlled-release matrix-type ocular insert that would maintain drug release in the eye's cul-de-sac by combining brimonidine tartrate with timolol maleate. Methods: To find the drug-polymer interactions, infrared experiments were first conducted. Solvent casting was used to create ocuserts loaded with sodium alginate. Nine formulations were created by varying the concentrations of the polymer (sodium alginate), plasticizer (glycerine), and cross-linking agent (calcium chloride) while maintaining the same medication concentration. The look, drug content, weight homogeneity, thickness homogeneity, % moisture absorption, percentage moisture loss, and in vitro release profile of the occuserts were all assessed for these formulations. Finally, the improved formulation was subjected to accelerated stability investigations and release kinetics.