This research explores the potential of Carica papaya leaf-extract to increase platelet count, addressing thrombocytopenia—a condition associated with low platelet levels and heightened bleeding risks. Carica papaya, a plant with historical medicinal use, particularly its leaf extract, contains bioactive compounds that may influence platelet production. Preclinical studies indicate a significant rise in platelet count, suggesting a potential therapeutic impact. However, clinical trials present varied outcomes, highlighting the need for standardized research protocols. Safety considerations, including potential adverse effects, warrant further examination. Despite the complexities, the prospect of Carica papaya as a therapeutic intervention for thrombocytopenia holds promise, pending additional comprehensive research and clinical validation. To investigate the potential role of fresh Carica papaya (C. papaya) leaf extract on hematological and biochemical parameters and toxicological changes in a murine model.