This abstract presents a succinct overview of the research study investigating the detrimental effects of stigma and discrimination on the physical and psychosocial well-being of children living with HIV. The study delves into the complex interplay between societal attitudes, healthcare access, mental health, and overall quality of life for these vulnerable children. A comprehensive literature review was conducted to analyze existing research on the subject. Additionally, qualitative and quantitative data were gathered through interviews, surveys, and medical records analysis. The study sample included children aged 6 to 17 years, living with HIV in diverse socio-cultural settings. This research underscores the urgent necessity of addressing stigma and discrimination to improve the physical and psychosocial well-being of children living with HIV. By fostering a stigma-free environment, enhancing healthcare accessibility, and strengthening support systems, we can significantly enhance the quality of life for these vulnerable children, allowing them to lead healthier, happier lives despite their medical condition.