The nursing profession has been influenced by medical advancements for a long time. Practice Based on Evidence (EBP) is one innovation that has influenced nursing throughout the world in the last and current decade. The main aim of the study is to Impact of Evidence-Based Practices In Medical - Surgical Nursing. Nurses' ability to educate and the quality of treatment they provide patients were both investigated in this chapter due to the research methodologies used to assess the Multilevel Integrated Training Programme in Evidence-Based Practice. The study's overarching goal was to determine how well the Multilevel Integrated Training Programme on EBP served its intended audiences nurse educators and clinical nurses—in terms of improving clinical practice and patient care.