Coronary illness can be treated as one of the major causes for mortality globally. On-time and Precise conclusion on the type of disease is significant for therapy and breakdown expectancy. Research scientists are working rigorously in their respective fields to reduce the death rate. The fundamental point of our proposed work is to build up a hybrid methodology using genetic algorithm (GA) with (RBF) radial basis function (GA-RBF) for the detection of coronary sickness with increased accuracy using the feature selection mechanism. The proposed system performance achieved an accuracy of 85.40% using 14 attributes, and the prediction accuracy increased to 94.20% with nine characteristics where the functionality of the proposed system performed much better after attribute reduction.