In many regions of the world, it is common practice to substitute generic prescription drugs for brand names, usually due to cost considerations. But generic replacement isn't a widely acknowledged technique in India. However, at the end of the day, the choice remains with the key stakeholders. The ultimate goal is affordable healthcare. The criteria for bioequivalence are to establish bioequivalence, the calculated 90% confidence interval for AUC and Cmax should fall within the bioequivalence range, usually 80-125%. The non-parametric 90% confidence interval of Tmax should lie within a clinically acceptable range. Chemically the generics should fall in the range of 90-110% of the brand drug. Government initiatives for promoting generic drugs prescription: MCI directives to prescribers to prescribe by generic names; Government directives regarding availability of generics at all government hospitals; Opening up of Jan Aushadi stores throughout country and Public private partnership for opening Jan Aushadi stores in remote areas with remunerations