Patients at the Centre for Plant Medicine Research (CPMR) in Ghana are prescribed and given an encapsulated combination of powdered Cassia sieberiana stem and root bark to relieve their gastric ulcer discomfort and dysmenorrhea. The absence of standardisation in the actual quantities of extracts obtained from product consumption poses substantial hurdles for the manufacturing process and the optimisation of therapeutic effects. The goal of the study was to use the stem and root bark to create and assess Cassia sieberiana capsules. Two distinct solvents were used for the extraction process: 70% ethanol (F2) and 100% ethanol (F1). CPMR compared these two formulations to the current product (MP1). Wet granulation was used to create the encapsulating granules, and MP1 was used to compare the granules' flow characteristics. The study of drug-excipient compatibility using TLC, UV, and FT-IR techniques. The MP1, F1, and F2 capsules underwent quality control testing utilising pharmacopoieal techniques. The organoleptic and physicochemical characteristics of the extracts indicated from the results that they were suitable for use in the production of oral capsules. The λmax values for MP1, F1, and F2 were 278 nm, 278 nm, and 276 nm, in that order. The results showed that for F1 and F2, the extract per dose of capsules was 27.84 ± 0.11 mg and 36.65 ± 0.03 mg, respectively. While MP1 showed a fair flow property, the granules of F1 and F2 had good flow qualities. Possible interactions between extracts and excipients were shown by FT-IR spectra. Nonetheless, TLC studies showed that the extracts and granules contained comparable components.