The body's most sensitive and important organs, the eyes' defense system prevents outside substances from entering. Since the medication is rapidly eliminated from the eye due to high tear fluid turnover and dynamics, conventional drug delivery techniques often result in low bioavailability and therapeutic responses. The in-situ gelling ophthalmic drug delivery system is one of the novel approaches created to address the issues with bioavailability. Viscose polymer-based liquids known as "in-situ gelling systems" display a sol-to-gel phase transition on the ocular surface as a result of a change in a particular physicochemical parameter, such as pH, ionic strength, or temperature. This formulation of pH-triggered in-situ gel systems allows for longer-lasting, therapeutically more effective, non-irritating, and stable drug release compared to traditional eye drops.