Getting food in good quality through effective delivery system to the target audience is a necessity. However, the desired quality of foods as they leave the point of production usually decline with time and this has raised series of packaging concerns. This work therefore sought to analyze the issues that bothered on food packaging especially the implications on food safety among others. It employed descriptive survey design. The population of the study comprised the 547 federal university academics in the Faculty of Agriculture in the South-Eastern Nigeria. A sample of 110 lecturers was drawn using purposive sampling technique. Four objectives, four research questions and four null hypotheses guided the study. The instrument for data collection was questionnaire. The reliability coefficient that was tested using the Cronbach Alpha method yielded 0.83 internal consistency. Data was analyzed using mean and standard deviation for research questions and z-test for the hypotheses. From the findings, it was revealed that food packaging has serious implications on food safety. Some challenges that affect food packaging include the rising cost of food, productivity, freshness, and sustainability. It was recommended that food safety and environmental protection should be the driving force behind food packaging to preserve human health.