Tomato (Solanum lycopersicum) belonging to the Solanaceae family and the genus Solanum is one of the most important vegetable crops after potato. Because of its widespread and health-promoting compounds, it is the model organism for research. Non-steroidal antiinflammatory drugs (NSAIDs) that are mainly used in the treatment of pain and inflammation with side effects like gastrointestinal irritation. Therefore, there is a resurgence to search for alternative anti-inflammatory drugs and medicines from natural sources. Hence, we aimed to evaluate anti-inflammatory potential of tomato (S. lycopersicum). Anti-inflammatory activity of tomato (S. lycopersicum) extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg was evaluated in Wistar albino rats in carrageenan induced paw edema animal model test. Inflammation was produced by administering 0.1 ml of 1% carrageenan into sub-plantar surface of rat hind paw to negative control group; 50 mg/kg (Group-I), 100 mg/kg (Group-II), 200 mg/kg (Group-III) tomato (S. lycopersicum) extracts and Aspirin 100 mg/kg (positive control) was administered intraperitoneally respectively. Results depicted that there was a dose dependent inhibition of hind paw edema volume following treatment with tomato (S. lycopersicum) extract. Furthermore, the anti-inflammatory effect of tomato (S. lycopersicum) extract at the dose level of 200 mg/kg was comparable with that of standard drug viz. Aspirin. Moreover, maximum inhibition of paw edema volume was observed at 12 h time interval at all the dose levels of tomato (S. lycopersicum) extract. In conclusion, this preliminary study proved anti-inflammatory potential of tomato (S. lycopersicum) extract. Therefore tomato (S. lycopersicum) extract could be considered for development natural anti-inflammatory drugs.