The development of genetic and epigenetic research altered certain long-held beliefs about health and disease. Microorganisms that have coevolved for millions of years with more advanced living forms have gained significance in this regard in recent years. A microbiome is made up of an organism's DNA and its bacteria, and it plays a role in maintaining health. Numerous bacteria live in the oral cavity, and keeping them under control helps to stabilize diseases of the mouth and the body as a whole. This article's goal is to update some ideas about the relationship between the oral microbiota and both general and oral health.