The study was undertaken to analyse the digitizing the operation of MSMEs challenges and opportunities in India. Despite extensive mitigation attempts, COVID-19 has infected more than 232 million people globally and caused more than 4,752,988 deaths as of September 2021. Demand for goods and services has plunged as businesses close and people stay at home, adding to rising unemployment and work stoppages. Small and medium-sized businesses may find that digitalisation can assist those overcome concerns about their operations. Marketing is the most significant and crucial issue for MSMEs. Digitization brings opportunities to MSMEs and how to face challenges in MSMEs. He went on to say that another crucial requirement for MSMEs' digital transformation is the availability of proper software that can turn their management systems into digital ones. However, only a few businesses have understood that digitization can help their activities become more dynamic and efficient, as well as increase their reach. Because they have high-quality Internet connectivity, a high degree of scientific and technological capability development, and wide information access, highly developed countries have the best level of digitisation of their own economies.