IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Diabetes Mellitus: A Brief Review

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Aiman Abbas Jafri , Juhi Aggarwal , Dr Jyoti Batra


“Diabetes mellitus” is a “disorder of carbohydrate metabolism” which is characterized by high blood glucose levels in the blood. It is caused either by impaired insulin secretion or loss of insulin activity due to the presence of insulin resistance and relative insulin deficiency at the target cells. “Type 1 diabetes mellitus (T1DM)” which makes up only 5 % of the cases is an auto immune disorder. In “type 2 diabetes mellitus (T2DM)” which accounts for more than 95 % of the cases, either the pancreas does not produce enough insulin or the insulin produced is not able to perform its function at the target site due to the presence of insulin resistance. As estimated by “International Diabetes Federation (IDF)” in 2015, the global burden of “diabetes aged between 20 to 79 years was about 415 million” and it was projected to rise to “642 million by 2040”. Present therapy for T2DM relies mainly on several approaches intended to reduce the hyperglycemia itself such as “Sulphonylureas, Metformin, α-glucosidase inhibitors”, and many more. However, these therapies have limited efficacy, limited tolerability and have significant mechanism-based side effects. Due to this reason, many traditional plant treatments are widely practiced throughout the world for the treatment of diabetes. These natural products are safe because they are more harmonious with biological systems and have less side effects compared to synthetic drugs. I n the present review we discussed about diabetes and their clinical management.

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