The performance of two PVC membrane electrodes containing DOP & DBP are described two electrodes are based on the use of DOP & DBP association compounds Diprone ( Sodium salt of 1-phenyl 1-2,3-Dimethyl 1-4-Methylaminomethane sulphonate – 5-pyrazolane ) and Piribedil is 1-( 3,4 Methylenediorcybenzyl ) – 4,2 –pyrimidyl) piperazine( P D)with TPB & PT. The developed electrodes were also analysis is some pharmaceutical formulations. The electrodes are characterized by a wide usable concentrations range of 1.01x10-5 – 1 x 10-2 M, Respectively for nearly all the studied electrodes at 25 oC by the use of ion exchangers membrane method. That can be use for the direct and measurement of Ions and other species. The use of ion – selective electrodes and potentiometric techniques in the analysis of drugs. Substances are reviewed. Ion–exchangers membrane technologies used for the characterization of these membranes are their applications were also reviewed for the benefit of readers. So that they can get all Information about the Ion- exchanger membranes at one platform.