ABSTRACT Mucoadhesive drug delivery systems utilize the bioadhesive properties of certain polymers, which become adhesive upon hydration. This characteristic allows these systems to target drugs to specific regions of the body for extended periods. Ranitidine, a histamine H2 receptor antagonist, is widely used to treat gastroesophageal reflux disease (GERD), a chronic gastrointestinal disorder involving the regurgitation of gastric contents into the esophagus. This study focuses on the preparation of a mucoadhesive delivery system loaded with ranitidine, aiming to enhance its efficacy and prolong its therapeutic effect in GERD treatment.