Herbal medications are gaining global popularity for healthcare applications. Herbal toothpastes, made from natural ingredients, are increasingly regarded as a preferable option for oral hygiene compared to chemical or synthetic formulations due to their ability to prevent cavities and other dental issues. These toothpastes are used to treat dental cavities, tartar, periodontal damage, foul breath, and gum disease. The key to developing a stable and effective herbal toothpaste is the elimination of all artificial ingredients commonly found in these products. Herbal toothpaste has garnered significant interest for its potential to reduce gingivitis. Studies on the effectiveness of these toothpastes have shown mixed results, suggesting that herbal toothpastes perform comparably to non-herbal alternatives. For those looking to minimize exposure to chemicals that may harm both oral and general health, organic toothpaste is a prudent and healthier choice. This article provides a comprehensive overview of the antibacterial and anti-inflammatory properties of various herbs used in toothpaste formulations.