Background: Chronic obstructive pulmonary disease susceptibility is known to be significantly influenced by genetic predisposition in addition to smoking (COPD). For COPD, a number of potential genes have been suggested, including surfactant protein B. (SFTPB). To clarify the role of SFTPB in COPD, however, comprehensive investigations in populations with various ethnic backgrounds and circumstances are needed. Aims & Objective : In a population, we looked into the relationship between SFTPB polymorphisms and lung function susceptibility to COPD. Methods & Materials : The SFTPB gene's four single nucleotide polymorphisms (SNPs) were genotyped in 480 COPD patients and 487 healthy individuals. Comparing genotype and allele frequencies between patients and controls allowed researchers to look into any possible connections between these SNPs and lung function. Additionally, associations between COPD susceptibility and haplotypes were evaluated. Results: The SFTPB exon polymorphism rs1130866 significantly reduced the risk of COPD in individuals (adjusted P = 0.003) and was linked to a rise in forced expiratory volume in one second (FEV1) (adjusted P=0.012). Conclusions: In the population, SFTPB polymorphisms are related to COPD risk and lung function.