Background: The objective of this study was to evaluate the prescribing patterns and associated risks of Proton Pump Inhibitors (PPIs). Objectives: 1. To analyze the prescribing pattern of PPIs. 2. To identify and report adverse drug reactions (ADRs). 3. To compare different drugs within the PPIs class. 4. To assess potential drug interactions. 5. To evaluate the risks associated with the use of PPIs. Materials and Methods: This prospective observational study was conducted at Parul Sevashram Hospital, involving data collection from 214 patients across various departments including general medicine, surgery, orthopedics, and respiratory, over a six-month period. Data analysis utilized graphical representations, charts, figures, tabulations, and statistical methods such as unpaired t-tests, chi-square tests, and ANOVA performed using MS-Excel. Results: During the study period, a total of 214 patients were included, with 99 males and 115 females. Most cases were from the medicine ward (52%), followed by the surgery ward (27.7%), and other departments including gynecology, pulmonary, respiratory, orthopedics, and others. Pantoprazole was the most frequently prescribed drug among the PPIs class. The analysis indicated that long-term/high-dose PPI use was associated with increased risks of fragility fractures, renal impairment, thrombocytopenia, and rebound hypersecretion of acid. Approximately 91% of PPIs were prescribed by brand name, with 85% of pantoprazole prescriptions combined with domperidone. Secondary sources such as MicroMedex and Drugs.com were found useful for reference purposes. Conclusion: This study highlights pantoprazole as the predominant PPI prescribed, and underscores the risks associated with prolonged or high-dose PPI therapy, including specific adverse effects. Utilization of databases like MicroMedex and Drugs.com proved beneficial as secondary resources for clinical decision-making.