In China and India, the perennial aquatic plant Nelumbo nucifera Gaertn has been utilized as a medicinal herb. For more than 400 years, it has been documented in China's most renowned medical book. In traditional medicine, several parts of the plant (leaves, seeds, flower, and rhizome) may be utilized. The various parts of the plant are said to have beneficial effects in the treatment of pharyngopathy, pectoralgia, spermatorrhoea, leucoderma, smallpox, dysentery, cough, haematemesis, epistaxis, haemoptysis, haematuria, metrorrhagia, hyperlipidaemia, fever, cholera, hepatopathy, and hyperdipsia in traditional medicine. Researchers have made significant attempts to validate N.nucifera's usefulness via rigorous pharmacological tests, based on traditional claims for its usage as a treatment for a variety of illnesses. N.nucifera has been found to have anti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycaemic, antidiarrhoeal, antifungal, antibacterial, antiinflammatory, and diuretic properties in pharmacological investigations. The plant has been used to isolate a broad range of phytoprinciples. The current study aims to bring together traditional, ethnobotanic, phytochemical, and pharmaceutical knowledge on Nucifera nucifera.