: In all, 100 staff nurses from Hospital, were interviewed to assess knowledge regarding selected emergency drugs among staff nurses. Methodology - A non experimental descriptive survey method exploratory in nature was conducted using a semi structured questionnaire which includes demographic data, multiple choice questions assessing knowledge about action, route, side effects, nurses responsibility regarding selected emergency drugs . Findings- Majority of staff nurses were able to answer about nurses responsibility but have average knowledge about the action and side effects. Conclusion- Study found that overall interpretation of knowledge in relation to nursing responsibility of medication administration shows 70% staff nurses have knowledge. Hence, continuing Education has to be increased for poor knowledge regarding emergency drugs which will prevent occupational hazard.