Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in the world today to treat inflammatory conditions. The NSAIDs used in the inflammatory conditions do not cure and remove the underlying cause of the disease but they only modify the inflammatory response to the diseases. Therefore, there is resurgence to search for new antiinflammatory agents. Current study was conducted with the main purpose of evaluating the anti-inflammatory activity of the ethanolic extracts of seeds of Tamarindus indica. Anti-inflammatory activity of ethanolic extracts of seeds of T. indica at doses of 250 mg/kg, 500 mg/kg and 750 mg/kg was evaluated in Wistar albino rats in carrageenan induced paw edema animal model test. Inflammation was produced by administering 0.1 ml of 1% carrageenan into sub-plantar surface of rat hind paw to negative control group; 250 mg/kg (Group-A), 500 mg/kg (Group-B), 750 mg/kg (Group-C) ethanolic extracts of seeds of T. indica and Diclofenac sodium 10 mg/kg (positive control) was administered orally respectively, Results inferred that there was statistically significant (p<0.01) inhibition in hind paw edema volume of rats in positive control group at 2 h, 4 h and 6 h. At 2 h and 4 h time intervals there was a statistically significant inhibition of paw edema volume was observed in Group-B (p<0.05) and Group-C (p<0.01). However, paw edema volume was significantly (p<0.01) reduced in Group-A (250 mg/kg), Group-B (500 mg/kg), and Group-C (750 mg/kg) at 6 h. The anti-inflammatory effect of ethanolic seed extract of T. indica at the dose level of 750 mg/kg was comparable with that of positive control (Diclofenac sodium). In conclusion, results of the present study clearly demonstrated that ethanolic seed extract of T. indica exhibited antidepressant activity. Hence, ethanolic seed extract of T. indica could be considered for development natural anti-inflammatory drugs.