Background: The impact of TB on HIV has led to an increase in HIV-Tuberculosis co-infection cases, which may have an impact on the severity of cognitive impairment in HIV positive people. Aims & Objectives: The study's goal is to examine cognitive performance in HIV-positive people with and without pulmonary tuberculosis. Methods and Materials: In this study, the cognitive function of HIV-positive people with and without tuberculosis will be assessed and compared. The study's participants are 60 HIV-positive people with pulmonary tuberculosis and 60 HIV-positive people without the disease. Using the International HIV Dementia Scale, cognitive function was examined. Results: In the IHDS, there is a big difference between the two groups in terms of memory, psychomotor speed, and overall score. In 73.33% of cases and 56.66% of controls, the total score was less than 10, which is significant for cognitive impairment. Future neuropsychological testing of HIV-positive, asymptomatic people is required to detect cognitive impairments at an early stage. Conclusion: The outcomes of the current investigation demonstrate how HIV's cognitive function is impacted by tuberculosis. Therefore, the co-infection with tuberculosis should be taken into account in the assessment and treatment plans.