The combinations of five-membered hetero-aromatic compounds such as is 1,2,4-oxadiazoles are of interest to the pharmaceutical industry and scientific data for their applications. Although there are many ways to prepare these compounds, new variations are constantly emerging as they provide many recreational and therapeutic benefits. This article presents a new method for the synthesis of 1,2,4-oxadiazole. The α,β-alkyne hydrazone was then treated with molecular iodine in the presence of NaHCO3 to give 1,2,4-oxadiazole in good yield. Then, the same reaction with CuI in the presence of %yields the corresponding synthesis 1,2,4-oxadiazole. In this study, the reaction between propargyl aldehyde and amidoxime was evaluated. This reaction only produces more compounds.