IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

A Pharmacological Study of Dynorphin

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Dr. Jyotsna Sharma1*, Dr. Shaktibala Dutta2 , Dr. Vaishali Lote3

Abstract

There are numerous types of opioid receptors and endogenous opioids present in the brain. There are other types of opioid receptors, including subtypes of I-' and K (ethylketocyc1azocine), as well as I-' (selective for morphine-like ligands), /) (enkephalins), and K (ethylketocyc1azocine). The enkephalins, 3-endorphin and related substances, and the dynorphins are the three main classes of endogenous opioid peptides, with each subclass having its own unique origins and distributions in the brain. One common misconception holds that all of the major ligand classes are equally selective for all of the key receptor types. A strong affinity for the I-' receptor is found in 3-endorphin, while lj receptors are targeted by enkephalins and K receptors by dynorphin. However, it is doubtful that the action of any of these ligands in vivo is restricted to one form of receptor alone, given they all have high affinity for more than one receptor type, and their extensive eNS distribution. This seems to be especially true of the dynorphins, a family of peptides that evolved from the prodynorphin precursor (proenkephalin B). Many members of this endogenous opioid class interact with high affinity with all three of the major opioid receptor types in the brain, unlike the enkephalins and the endorphins. The fact that they are not analgesic in the brain, though they might be in the spinal cord, makes them practically unique among endogenous opioids

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