Throughout history, medicinal plants have played a crucial part in providing medicine. The therapeutic benefits of these plants have been extensively recorded in traditional medical systems, such as Indian, Chinese, and Korean medicine, and are used to treat chronic inflammatory diseases. Millions of people worldwide suffer from the discomfort of arthritis, one of the dangerous chronic inflammatory diseases. Arthritis is an inflammatory disease that can spread quickly, damaging cartilage or bone in the joints as a result of several inflammatory mediators. NSAIDs, DMARDs, and corticosteroids are currently the most often recommended medications for the treatment of inflammation or arthritic pain. Long-term usage of them could have a wide range of harmful effects. Therefore, it is imperative to discover alternative treatment agents with the least amount of hazardous side effects. The people of the Eastern Himalayan region have long utilised a wide variety of medicinal herbs that have strong anti-inflammatory and/or anti-arthritic effects. There haven't been many studies conducted on Himalayan medicinal plants to confirm their therapeutic benefits. Thus, novel and more affordable medications for treating various types of inflammation may be found through research on plant materials and traditional medicine expertise. This review focuses on the Eastern Himalayan medicinal herbs that have demonstrated promise therapeutic effectiveness against inflammatory illnesses, along with innovative methods for preparing these plants.